Exemestane has a good tolerability, has mild side effects. The Common side-effects including hot flashes, nausea, insomnia, depression, headaches, dizziness, pain, rash, abdominal pain, anorexia, vomiting, depression, hair loss, body or lower extremity edema, constipation and indigestion. Exemestane is an effective steroidal aromatase inactivator with superior tolerability, safety and efficacy in the adjuvant, neo-adjuvant and metastatic therapy of breast cancer. Exemestane is used for adjuvant treatment after tamoxifen treatment. The post-menopausal women patients with advanced breast cancer can accept such treatment.
Clinical trials show that the standard dose of exemestane is 25mg daily, There are 7.4% of patients give up treatment because of side effects In an interview with tamoxifen and exemestane adjuvant treatment of early breast cancer patients. The most commonly reported adverse reactions were hot flashes (22%), arthralgia (18%) and fatigue (16%). There are 2.8% of the patients appear side effects In all patients with advanced breast cancer. The most commonly reported adverse reactions were hot flashes (14%) and nausea (12%). Most Exemestane side effects is a normal pharmacology response (hot flushes), Because estrogen is blocked. Exemestane treatment for advanced breast cancer patients Rare with thrombocytopenia or leukopenia report. There are 20% of patients with episodic lymphopenia, Particularly past history of lymphopenia, but these patients had no symptoms of viral infection. There is no Exemestane side effect report in the treatment of early breast cancer.
Overall, exemestane has a good tolerability, with mild to moderate side effects. In the IES study, The rate of patients discontinued treatment is 6.3% of exemestane, Tamoxifen group was 5.1%. Although women may get the health from two new drugs, 4% of women taking these two drugs. Exemestane has no side effects than either drug. Subjects were 4560 postmenopausal women from Canada, the United States, France and Spain. Half of them taking exemestane, After three years, researchers found that only 11 of these people who suffer from breast cancer, without taking the drug have 32 people suffering from breast cancer. Exemestane can prevent breast cancer, The drug has been in the domestic market. If the people without breast cancer take exemestane before can reduce 60% the risk of breast cancer. Exemestane is an effective steroidal aromatase inactivator with superior tolerability, safety and efficacy in the adjuvant, neo-adjuvant and metastatic therapy of breast cancer.