Health and Medicine

Breast cancer is a cancer, which develops in breast tissues. It affects ducts carrying milk and glands making milk. Gland making milk is known as lobules. It may occur in both men and women but it is more common in women and is rare in men. Breast cancer can affect different tissues of the breast. It can affect ducts or tube moving milk from the breast to the nipple or milk producing parts lobules. It may be invasive or spreading from the milk duct or lobule to other tissues in the breast. It may also be non-invasive or confined to a smaller part of breast or in situ. Breast cancer in situ may affect the lining of the milk ducts or lobules and not invade nearby tissues. It may progress to invasive cancer.

Many patients may suffer from estrogen sensitive breast cancer. These types of breast cancer have receptors for estrogen on the surface of their cells. They are also known as estrogen receptor-positive cancer or ER-positive cancer. Some breast cancers may HER2-positive. HER2 is a gene helping cells growth, division or repair. This type of breast cancer quickly spreads and is more likely to be recurring.

Inflammatory breast cancer takes lives of most of the people who develop it. It is a very “hostile” type of cancer, which thankfully, is also rare. It gets its name from the inflammation the breasts of the victim develop. Contrary to other forms of cancer, inflammatory breast cancer can develop in relatively younger females, too. Rarely do men develop IBC.

In Inflammatory breast cancer, the cancer cells block lymph vessels of the breast. This gives rise to the apparent inflammation and redness of the breast of a person diagnosed with IBC. Other forms of cancer usually develop in women as they age, but that is not the case with IBC. It can occur in young women, too. It is also said that African American women are more prone to developing IBC, and at a younger age too, compared to White women.

Exemestane has a good tolerability, has mild side effects. The Common side-effects including hot flashes, nausea, insomnia, depression, headaches, dizziness, pain, rash, abdominal pain, anorexia, vomiting, depression, hair loss, body or lower extremity edema, constipation and indigestion. Exemestane is an effective steroidal aromatase inactivator with superior tolerability, safety and efficacy in the adjuvant, neo-adjuvant and metastatic therapy of breast cancer. Exemestane is used for adjuvant treatment after tamoxifen treatment. The post-menopausal women patients with advanced breast cancer can accept such treatment.

Clinical trials show that the standard dose of exemestane is 25mg daily, There are 7.4% of patients give up treatment because of side effects In an interview with tamoxifen and exemestane adjuvant treatment of early breast cancer patients. The most commonly reported adverse reactions were hot flashes (22%), arthralgia (18%) and fatigue (16%). There are 2.8% of the patients appear side effects In all patients with advanced breast cancer. The most commonly reported adverse reactions were hot flashes (14%) and nausea (12%). Most Exemestane side effects is a normal pharmacology response (hot flushes), Because estrogen is blocked. Exemestane treatment for advanced breast cancer patients Rare with thrombocytopenia or leukopenia report. There are 20% of patients with episodic lymphopenia, Particularly past history of lymphopenia, but these patients had no symptoms of viral infection. There is no Exemestane side effect report in the treatment of early breast cancer.